Clinical and Epidemiological Characteristics of Human Metapneumovirus Infection in Children in Kyrgyzstan

Madina Mambetova; Zuura Dzholbunova; Meerim. Bayalieva; Asel Balabasova; Zhumagul  Anarbaeva; Poshitha Kondadasula; Zhanara  Asanbekova

Madina Mambetova Department of Pediatric Infectious Diseases, Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyz Republic.
Zuura Dzholbunova Department of Pediatric Infectious Diseases, Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyz Republic.
Meerim. Bayalieva Department of Pediatric Infectious Diseases, Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyz Republic
Asel Balabasova Republican Clinical Infectious Diseases Hospital, Bishkek, Kyrgyz Republic.
Zhumagul Anarbaeva Department of Infectious Diseases, Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyz Republic.
Poshitha Kondadasula Department of General Medicine, A C Subba Reddy Government Medical College, Nellore, Andhra Pradesh, India.
Zhanara Asanbekova Department of Propaedeutics of Childhood Diseases, Kyrgyz State Medical Academy named after Akhunbaev, Bishkek, Kyrgyz Republic

Keywords: Human Metapneumovirus, Acute Respiratory Viral Infections, Epidemiology, Children, Pneumonia

Abstract

Introduction: Human metapneumovirus (hMPV) has recently emerged as the primary cause of acute respiratory viral infection (ARVI). Like other countries in Central Asia, Kyrgyzstan has experienced a high prevalence of ARVI infections, which sometimes reach epidemic levels. The purpose of this study was to investigate the presence of acute respiratory viruses such as parainfluenza, rhinovirus, adenovirus, respiratory syncytial virus, metapneumovirus, and bocavirus in the etiological structure of ARVI in Kyrgyzstan.
Methods: This cross-sectional study included children diagnosed with ARVIs and divided them into three age groups: Group I (n = 30, 0–12 months), Group II (n = 24, 1–3 years), and Group III (n = 8, 4–7 years). Polymerase chain reaction was performed on nasal secretions collected from children hospitalised for severe ARVIs.
Results: hMPV infection is more common in children under 10 years of age, and the severity of the illness is high, with a mortality rate of 7.0%–10.0% in young children. Several factors, including gestational pregnancy, anaemia, history of ARVIs, and postpartum complications, can affect the severity of the condition. Pneumonia was more common in children in Groups II-III (33.3%, 62.5%, and 50.0%, respectively).
Conclusion: ARVI was the most frequently reported illness among the patients, and the severity of the illness ranged from 70.0–75.0%.

How to cite this article:
Mambetova M, Dzholbunova Z, Bayalieva M,
Balabasova A, Anarbaeva Z, Asanbekova Z,
Kondadasula P. Clinical and Epidemiological
Characteristics of Human Metapneumovirus
Infection in Children in Kyrgyzstan. J Commun
Dis. 2024;56(2):15-21.

DOI: https://doi.org/10.24321/0019.5138.202427

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