Comparative Sensitivity of the Test With Tuberculosis Recombinant Allergen and Tuberculin Skin Test in Children and Adolescents with Newly Diagnosed Tuberculosis

Altynai  Baitelieva; Tologon  Chubakov; Azyi  Shayimbetov; Meerim  Bayalieva; Elnura  Usubalieva; Elmira  Akmatova; Gulkayir  Murzabekova; Yethindra  Vityala; Tugolbai  Tagaev

Altynai Baitelieva Department of Scientific Research Management, Occupational Pathology with a Course of Haematology, IK Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan.
Tologon Chubakov Department of Phthisiopulmonology, Kyrgyz State Medical Institute of Retraining and Advanced Training named after SB Daniyarova, Bishkek, Kyrgyzstan
Azyi Shayimbetov 3Department of Children’s Infectious Diseases, Occupational Pathology with a Course of Haematology, IK Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan.
Meerim Bayalieva Department of Children’s Infectious Diseases, Occupational Pathology with a Course of Haematology, IK Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan
Elnura Usubalieva Department of Phthisiology, Occupational Pathology with a Course of Haematology, IK Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan.
Elmira Akmatova Department of Fundamental Disciplines, International School of Medicine, Educational, Research and Production of the International University of Kyrgyzstan, Bishkek, Kyrgyzstan.
Gulkayir Murzabekova Department of Basic and Clinical Pharmacology named after Academician MT Nanaeva
Yethindra Vityala Honorary International Faculty, AJ Research Centre, AJ Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, India.
Tugolbai Tagaev Department of Hospital Internal Medicine, Occupational Pathology with a Course of Haematology, IK Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan

Keywords: Tuberculosis, Mantoux Tuberculin Skin Test, Recombinant TB Allergen, ESAT-6 Protein, CFP-10 Protein

Abstract

Background: This article emphasizes the importance of detecting latent tuberculosis infection in children aged 17 years or younger. This study examined the effectiveness of two contemporary diagnostic methods: the traditional Mantoux tuberculin skin test (TST) using 2 TE of PPD-L and a test that utilizes recombinant TB allergen (ATR).
Materials and Methods: The sensitivity of ATR and TST with 2 TE of PPD-L was compared in family medicine centers in the Bishkek and Chui regions for children and adolescents aged 1-17 years. A total of
4,899 tests were conducted in these areas.
Results: The infiltrate measurement for 43.4% of the children fell within the range of 5-14 mm, and 47.2% had at least 15 mm when using 2 TE of PPD-L for TST. Among the 3581 children aged 7-14 years, 2371 (66.2%) tested negative, 1210 (33.8%) tested positive, and 558 (46.1%) showed hyperergic reactions. In comparing TST and ATR tests for adolescents, 11 (11.0%) cases showed positive reactions to both, 4 (7.8%) had hyperergic reactions, and 419 (76.9%) tested negative.
Conclusions: ATR was more effective than TST with 2 TE PPD-L in eliminating post-vaccinal allergies in children under 6 years of age for the diagnosis of latent tuberculosis infection (8 times more often; 78.3% vs. 9.4%, p < 0.05).

How to cite this article:
Baitelieva A, Chubakov T, Shayimbetov A, Bayalieva M, Usubalieva E, Akmatova E, Murzabekova G, Vityala Y, Tagaev T. Comparative Sensitivity of the Test With Tuberculosis Recombinant Allergen and Tuberculin Skin Test in Children and Adolescents with Newly Diagnosed Tuberculosis. J Commun Dis. 2023;55(4):131-139.

DOI: https://doi.org/ 10.24321/0019.5138.202366

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Comparative Sensitivity of the Test With Tuberculosis Recombinant Allergen and Tuberculin Skin Test in Children and Adolescents with Newly Diagnosed Tuberculosis

Abstract

References

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