Comparison of the Therapeutic Effect of Cranberry against Nitrofurantoin in Preventing Recurrent Cystitis during Pregnancy
Abstract
Background: Cystitis is an inflammation of the urinary bladder due to bacterial or non-bacterial causes. Signs and symptoms of cystitis are difficult to distinguish in pregnancy. Nitrofurantoin can stop the symptoms of cystitis and may lower the chance of some pregnancy problems including preterm delivery. Though cranberry is used to prevent or treat urinary tract infections, scientific evidence to support the use of cranberry for the prevention or treatment of cystitis is lacking.
Objective: To evaluate the therapeutic effectiveness of cranberry in preventing recurrent cystitis during pregnancy and compare it with that of nitrofurantoin
Methods: One hundred pregnant women were divided as follows: Group 1 included 50 women with cystitis kept on nitrofurantoin)100 mg per day) given orally till the gestation age reached 32 weeks, and Group 2 included 50 women with cystitis kept on cranberry capsule (one capsule per day) given orally till the end of gestation. Patients were clinically examined and urine samples were analyed monthly to evaluate the presence of bacteria and pus cells.
Results: Nitrofurantoin and cranberry showed an increase in the number of asymptomatic patients on comprehensive clinical examination; also, urinalysis showed that the number of patients with the absence of bacteria and pus cells in urine increased and there was a decrease in the number of positive (++) category cases, which indicated that the pregnant women showed improvement.
Conclusion: Both nitrofurantoin and cranberry were therapeutically effective in the treatment of cystitis, but the therapeutic effectiveness of nitrofurantoin is higher as compared to that of cranberry.
How to cite this article:
Nawfal D, Shamkhee E. Comparison of the Therapeutic Effect of Cranberry against Nitrofurantoin in Preventing Recurrent Cystitis during Pregnancy. J Commun Dis. 2023; 55(4): 23-28.
DOI: https://doi.org/10.24321/0019.5138.202349
References
Goldman JD, Julian K. Urinary tract infections in solid organ transplant recipients: guidelines from
the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019
Sep;33(9):e13507. [PubMed] [Google Scholar]
Duane S, Vellinga A, Murphy AW, Cormican M, Smyth A, Healy P, Moore M, Little P, Devane D. COSUTI:
a protocol for the development of a core outcome set (COS) for interventions for the treatment of
uncomplicated urinary tract infection (UTI) in adults. Trials. 2019;20(1):106. [PubMed] [Google Scholar]
Behzadi P, Behzadi E, Yazdanbod H, Aghapour R, Cheshmeh MA, Omran DS. A survey on urinary tract
infections associated with the three most common uropathogenic bacteria. Maedica (Bucur). 2010
Apr;5(2):111-5. [PubMed]
Heitmann K, Nordeng H, Holst L. Pregnancy outcome after use of cranberry in pregnancy--the Norwegian
Mother and Child Cohort Study. BMC Complement Altern Med. 2013 Dec 7;13:345. [PubMed] [Google
Scholar]
Nordeng H, Bayne K, Havnen GC, Paulsen BS. Use of herbal drugs during pregnancy among 600 Norwegian
women in relation to concurrent use of conventional drugs and pregnancy outcome. Complement Ther Clin
Pract. 2011;17(3):147-51. [PubMed] [Google Scholar]
Hanlon JT, Perera S, Drinka PJ, Crnich CJ, Schweon SJ, Klein-Fedyshin M, Wessel CB, Saracco S, Anderson
G, Mulligan M, Nace DA. The IOU Consensus Recommendations for empirical therapy of cystitis
in nursing home residents. J Am Geriatr Soc. 2019 Mar;67(3):539-45. [PubMed] [Google Scholar]
Micali S, Isgro G, Bianchi G, Miceli N, Calapai G, Navarra M. Cranberry and recurrent cystitis: more than
marketing? Crit Rev Food Sci Nutr. 2014;54(8):1063-75. [PubMed] [Google Scholar]
Luczak T, Swanoski M. A review of cranberry use for preventing urinary tract infections in older adults.
Consult Pharm. 2018 Aug 1;33(8):450-3. [PubMed] [Google Scholar]
MiP: Ultrasound reference manual for pregnancy dating: Developed for the Assessing the Safety of
Antimalarials during early Pregnancy (ASAP) Study through support from the Malaria in Pregnancy
Consortium (MiPc). University of Washington: Department of Global Health; 2012.
Fung R, Villar J, Dashti A, Ismail LC, Staines-Urias E, Ohuma EO, Salomon LJ, Victora CG, Barros FC, Lambert
A, Carvalho M, Jaffer YA, Noble JA, Gravett MG, Purwar M, Pang R, Bertino E, Munim S, Min AM, McGready R, Norris SA, Bhutta ZA, Kennedy SH, Papageorghiou AT, Ourmazd A; International Fetal and Newborn Growth
Consortium for the 21st Century (INTERGROWTH-21st). Achieving accurate estimates of fetal gestational age
and personalised predictions of fetal growth based on data from an international prospective cohort study:
a population-based machine learning study. Lancet Digit Health. 2020 Jun 23;2(7):e368-75. [PubMed]
[Google Scholar]
Karah N, Rafei R, Elamin W, Ghazy A, Abbara A, Hamze M, Uhlin BE. Guideline for urine culture
and biochemical identification of bacterial urinary pathogens in low-resource settings. Diagnostics (Basel).
Oct 16;10(10):832. [PubMed] [Google Scholar]
Rank EL, Lodise T, Avery L, Bankert E, Dobson E, Dumyati G, Hassett S, Keller M, Pearsall M, Lubowski T, Carreno JJ. Antimicrobial susceptibility trends observed in urinary pathogens obtained from New York state. Open Forum Infect Dis. 2018 Nov;5(11):ofy297. [PubMed] [Google Scholar]
Committee Opinion No. 717: sulfonamides, nitrofurantoin, and risk of birth defects. Obstet Gynecol. 2017 Sep;130(3):e150-2. [PubMed]
Cutts JC, Agius PA, Lin Z, Powell R, Moore K, Draper B, Simpson JA, Fowkes FJ. Pregnancy-specific malarial
immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review. BMC Med.
;18(1):14. [PubMed] [Google Scholar]
Shi H, Kang CI, Cho SY, Huh K, Chung DR, Peck KR. Follow-up blood cultures add little value in the
management of bacteremic urinary tract infections. Eur J Clin Microbiol Infect Dis. 2019 Apr;38(4):695-702.
[PubMed] [Google Scholar]
Gomila A, Carratalà J, Eliakim-Raz N, Shaw E, Wiegand I, Vallejo-Torres L, Gorostiza A, Vigo JM, Morris S, Stoddart M, Grier S, Vank C, Cuperus N, dan Heuvel LV, Vuong C, MacGowan A, Leibovici L, Addy I, Pujol M; COMBACTE MAGNET WP5 RESCUING Study Group and Study Sites. Risk factors and prognosis of complicated urinary tract infections caused by Pseudomonas aeruginosa in hospitalized patients: a retrospective multicenter
cohort study. Infect Drug Resist. 2018;11:2571-81. [PubMed] [Google Scholar]
McKinnell JA, Stollenwerk NS, Jung CW, Miller LG. Nitrofurantoin compares favorably to recommended agents as empirical treatment of uncomplicated urinary tract infections in a decision and cost analysis. Mayo
Clin Proc. 2011 Jun;86(6):480-8. [PubMed] [Google Scholar]
Huttner A, Verhaegh EM, Harbarth S, Muller AE, Theuretzbacher U, Mouton JW. Nitrofurantoin
revisited: a systematic review and meta-analysis of controlled trials. J Antimicrob Chemother. 2015
Sep;70(9):2456-64. [PubMed] [Google Scholar]
Le J, Briggs GG, McKeown A, Bustillo G. Urinary tract infections during pregnancy. Ann Pharmacother.
;38(10):1692-701. [PubMed] [Google Scholar]
Prytherch JP, Sutton ML, Denine EP. General reproduction, perinatal-postnatal, and teratology
studies of nitrofurantoin macrocrystals in rats and rabbits. J Toxicol Environ Health. 1984;13(4-6):811-23.
[PubMed] [Google Scholar]
Fekete T. 5 days of nitrofurantoin was equivalent to 3 days of trimethoprim-sulfamethoxazole for women
with non-complicated cystitis. Evid Based Med. 2008;13(3):80. [PubMed] [Google Scholar]
Hisano M, Bruschini H, Nicodemo AC, Srougi M. Cranberries and lower urinary tract infection
prevention. Clinics (Sao Paulo). 2012;67(6):661-8. [PubMed] [Google Scholar]
Jepson RG, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev.
;(1):CD001321. [PubMed] [Google Scholar]
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