Evaluation of Carvacrol and its Receptor (Ubiquinone-c-reductase) as a Potential Anti-malarial Drug

  • Anu Bansal School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, India.
  • Neeta Raj Sharma School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, India. https://orcid.org/0000-0001-8638-4217
  • Atul K Upadhyay School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, India.
  • Shweta Kaushik National Centre for Disease Control, 22-Sham Nath Marg, Delhi, India.
  • TG Thomas National Centre for Disease Control, 22-Sham Nath Marg, Delhi, India.
Keywords: Carvacrol, Oreganum vulagre, Malaria and Malarone

Abstract

In recent times natural products are exploiting for its medicinal properties due to its minimum side-effects. Carvacrol which is one of the monoterpene’s isolated from the essential oil of Oreganum vulgare possesses various antimicrobial, anti-oxidant and anti-cancerous activities. Therefore, in this present study carvacrol was selected to study its anti-malarial activity. A comparative study of commercially available drugs (Malarone) and carvacrol was conducted to understand the putative mechanism of action of carvacrol and its potential as a natural anti-malarial drug. Way2drug tool was used to predict the biological activity of the compound using the PASS Online server to predict the target protein of carvacrol. Further, Ubiquinone-c-reductase was selected for molecular docking with carvacrol because Malarone cures malaria by inhibiting the activity of enzyme. Ubiquinone-c-reductase is the key enzyme of the electron transport chain. It resulted that the amino acids positioned at 264-267 in chain ‘A’ of ubiquinone-c-reductase, were efficiently targeted by carvacrol with a minimum energy value of -5.4 Kcal/ mol. The present study resulted that carvacrol behaves as a natural blocker for ub-c-reductase may serve as a possible mechanism to develop carvacrol as a potential herbal anti-malarial drug.

How to cite this article:
Bansal A, Sharma NR, Upadhyay AK, Kaushik S, Thomas TG. Evaluation of Carvacrol and its Receptor (Ubiquinone-c-reductase) as a Potential Anti-malarial Drug. J Commun Dis 2019; 51(4): 16-20.

DOI: https://doi.org/10.24321/0019.5138.201932

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Published
2020-02-24

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