Exploring Squalene and Rhodoxanthin from Hylocereus undatus as a Therapeutic Agent for the Treatment of Human Liver Cancer using Docking Analysis

  • Padmavathy K Research Scholar, Department of Zoology, Presidency College, Chennai, India.
  • Sivakumari K Associate Professor, Department of Zoology, Presidency College, Chennai, India.
  • Rajesh S Research Scholar, Department of Zoology, Presidency College, Chennai, India.
Keywords: Dragon Fruit, Squalene, Rhodoxanthin, Apoptotic Proteins, Liver Cancer

Abstract

Introduction: The dragon fruit H. undatus contains several active phyto-compounds, which act as good antioxidant, anti-inflammatory, and anti-cancer agents. To explore the apoptotic potential of these phyto-compounds, it would be apt to screen the interaction of these compounds with apoptotic proteins via., in silico docking studies.
Method: The current study was planned to evaluate the docking interaction of selected GC-MS spectrum components from H. undatus (squalene and rhodoxanthin) with apoptotic proteins (AIF, Apaf-1, BAK, caspase 8, and RIP) by PatchDock docking algorithm.
Results: The docking interaction showed that rhodoxanthin docks well with apoptotic proteins, and rhodoxanthin is recommended by the Lipinski rule as the best treatment for liver cancer.
Conclusion: The application of rhodoxanthin as a potential and natural therapeutic agent to cure diseases is validated by docking results.

How to cite this article:
Padmavaty K, Sivakumari K, Rajesh S. Exploring Squalene and Rhodoxanthin from Hylocereus undatus as a Therapeutic Agent for the Treatment of Human Liver Cancer using Docking Analysis. Chettinad Health City Med J. 2022;11(2):24-32.

DOI: https://doi.org/10.24321/2278.2044.202213

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Published
2022-06-30